A RAPID DIAGNOSTIC TEST FOR SICKLE CELL ANEMIA
نویسندگان
چکیده
منابع مشابه
A rapid diagnostic test for sickle cell anemia.
S ICKLE cell anemia is a congenital chronic hemolytic type of anemia characterized hematologically by the development of oat-shaped and sickle-shaped erythrocytes. Other cellular abnormalities which are due to excessive blood de-’ struction and active blood formation are also seen in blood smears. Six to IO per cent of Negroes possess the sickle trait 2p 3; their red blood cells have the capaci...
متن کاملA simple, rapid, low-cost diagnostic test for sickle cell disease.
This communication describes a very simple, rapid and inexpensive point-of-care diagnostic test for sickle cell disease (SCD) that can conclusively differentiate between blood samples from normal healthy individuals, sickle cell trait carriers and SCD patients using the characteristic blood stain patterns produced by each sample on paper.
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We evaluated the most common indices to compare their sensitivity and specificity to introduce the most sensitive and specific index. We systematically searched five international indexing databases up to Dec 2018. For each index, we measured the diagnostic odds ratio (DOR), as well as summary ROC (SROC) curve which was used to compare the performance of each index. Deeks̕ tests of all discrimin...
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Background: Hemoglobin S arises is the result of a point mutation (A-T) in the sixth codon on the -globin gene on chromosome 11 causing sickle cell anemia. The presence of fetal hemoglobin in infancy plays a relatively protective role for vaso-occlusive symptoms that are the major contributor for the morbidity and mortality among patients with sickle cell anemia. hydroxyurea, an s-phase-specif...
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ژورنال
عنوان ژورنال: Blood
سال: 1949
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v4.1.66.66